Selected Protein modification Terms — English (MOD)

Selected terminology for Protein modification. Original publisher/project: Protein modification. Credit: Protein modification project contributors. Original source: https://purl.obolibrary.org/obo/mod.owl; captured download: https://raw.githubusercontent.com/HUPO-PSI/psi-mod-CV/master/PSI-MOD.owl; project record: https://obofoundry.org/ontology/mod.html. Retrieved 2026-11-07. Version: http://purl.obolibrary.org/obo/mod/1.40.0/mod.owl. Original artifact SHA-256: 35e1a1e7f1802c5d700e5bfc3804b5346c618243f85f76ff13264367e66c6da3. On 2026-11-08 the saved artifact was byte-for-byte matched to https://raw.githubusercontent.com/HUPO-PSI/psi-mod-CV/7199e3d7ff1398db65ca3fc3443e7b406451211f/PSI-MOD.owl, commit 7199e3d7ff1398db65ca3fc3443e7b406451211f. Original/public license: CC-BY-4.0, confirmed in this same repository commit at https://raw.githubusercontent.com/HUPO-PSI/psi-mod-CV/7199e3d7ff1398db65ca3fc3443e7b406451211f/LICENSE; no license is inferred solely from an index declaration. Source IDs, original text, and individual source citations are retained. Languages: English; explicit tags are retained; untagged English is inferred from the OLS index and noted in private source history. No regional or cross-language equivalence is inferred. Includes active own-project owl:Class primary labels and explicit exact synonyms only. Deprecated classes, general alternative labels, external namespaces, definitions, relationships and imports are excluded. This is a selected subset, not the full ontology. Semantic review is ongoing. The curated resource library does not claim upstream institutional authorization or endorsement.

Curator: Oliver Bennett

Languages shown reflect this page; source translations may cover only some concepts.

English
dCDI-NNMe2+ArgUnrated protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimideUnrated
dihydroxylated residueUnrated Hy2ResUnrated
2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acidUnrated (2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acidUnrated 3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedioneUnrated 6,7 Dione (from Tryptophan)Unrated L-tryptophyl quinoneUnrated MOD_RES TryptophylquinoneUnrated N-(3-carboxy-1-oxopropyl)-L-tryptophanUnrated TrpQUnrated
L-histidine removalUnrated
3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoylUnrated TMT6plex reporter+balance reagent acylated residueUnrated
2-azanyl-3-(phosphonosulfanyl)propanoic acidUnrated (2R)-2-amino-3-(phosphonosulfanyl)propanoic acidUnrated ACT_SITE Phosphocysteine intermediateUnrated cysteine phosphate thioesterUnrated MOD_RES PhosphocysteineUnrated PCysUnrated S3-phosphocysteineUnrated S-phospho-L-cysteineUnrated S-phosphonocysteineUnrated S-phosphorylated L-cysteineUnrated
(2S,3S,2'R)-3-methyllanthionine sulfoxideUnrated (2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acidUnrated (2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acidUnrated 3-methyl-L-lanthionine S-oxideUnrated 3-methyl-L-lanthionine sulfoxideUnrated CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys)Unrated S-oxy-3-methyllanthionineUnrated
Applied Biosystems cleavable ICAT(TM) heavyUnrated icatheavyUnrated
(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acidUnrated (2S,2'S)-6,6'-iminobis(2-aminohexanoic acid)Unrated 6-(N6-L-lysino)-L-norleucineUnrated L-lysinonorleucineUnrated lysinonorleucineUnrated lysinorleucine [misspelling]Unrated lysylnorleucineUnrated N6-[(5S)-5-amino-5-carboxypentyl]-L-lysineUnrated
(2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acidUnrated 4,5-dihydroxylated L-lysineUnrated 4,5-dihydroxy-L-lysineUnrated 45Hy2LysUnrated alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acidUnrated delta,gamma-dihydroxylysineUnrated MOD_RES 4,5-dihydroxylysineUnrated
D-PheUnrated D-phenylalanineUnrated MOD_RES D-phenylalanineUnrated (R)-2-amino-3-phenylpropanoic acidUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ117YUnrated iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosineUnrated mTRAQ heavy on YUnrated
(18)O substituted residueUnrated
(2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acidUnrated (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acidUnrated (2S,3R,4S)-4-hydroxyisoleucineUnrated (3R,4S)-4-hydroxyisoleucineUnrated gamma-hydroxyisoleucineUnrated MOD_RES (3R,4S)-4-hydroxyisoleucineUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ8plex-118 reporter+balance reagent O3-acylated serineUnrated
iodinated tyrosineUnrated ITyrUnrated
4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residueUnrated AEBSFUnrated
FucUnrated fucosylated residueUnrated
(2S)-2-amino-3-methylbutanamideUnrated L-valine amideUnrated MOD_RES Valine amideUnrated valinamideUnrated ValNUnrated
(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminiumUnrated (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazaniumUnrated (2S)-2-trimethylammonio-3-hydroxypropanoic acidUnrated MOD_RES N,N,N-trimethylserineUnrated N,N,N-trimethyl-L-serineUnrated N,N,N-trimethylserine cationUnrated N,N,N-trimethylseriniumUnrated
3HyAsnUnrated 3-hydroxy-L-asparagineUnrated hydroxylationnUnrated monohydroxylated asparagineUnrated
2-azanyl-3-methylpentanoic acidUnrated (2R,3S)-2-amino-3-methylpentanoic acidUnrated 3-methyl-norvalineUnrated allo-D-isoleucineUnrated alpha-amino-beta-methylvaleric acidUnrated D-allo-isoleucineUnrated D-IleUnrated D-threo-isoleucineUnrated MOD_RES D-allo-isoleucineUnrated
Hexosamines (GalN, GlcN)Unrated hexosaminylated residueUnrated
methylated aspartic acidUnrated
manganese containing modified residueUnrated MnResUnrated
fucosylated biantennary (-2 galactose) N4-glycosylated asparagineUnrated
ester crosslinked residuesUnrated
L-lysinoalanine (Lys-Cys)Unrated Lysinoalanine (from Cysteine)Unrated
2-aminoacetamideUnrated 2-aminoethanamideUnrated 2-azanylethanamideUnrated amidated glycineUnrated glycinamideUnrated glycine amideUnrated GlyNUnrated MOD_RES Glycine amideUnrated
(2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acidUnrated 5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysineUnrated O5-glucosylgalactosyl-L-hydroxylysineUnrated OGlcGal5HyLysUnrated
dHex1Hex3HexNAc6 N4-glycosylated asparagineUnrated
alpha-amino methylated residueUnrated N2MeResUnrated
(2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acidUnrated CARBOHYD O-linked (Gal) threonineUnrated CARBOHYD O-linked (Hex)Unrated O3-galactosylthreonineUnrated O-galactosyl-L-threonineUnrated OGalThrUnrated O-glycosylthreonineUnrated
2-(2-aminosuccinimidyl)pentanedioic acidUnrated
halogenated tyrosineUnrated HalTyrUnrated
isotope tagged reagent N-acylated residueUnrated
(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer]Unrated 5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acidUnrated CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys)Unrated L-proline 5-hydroxy-oxazole-4-carbothionic acidUnrated L-proline 5-hydroxyoxazole-4-carbothionic acidUnrated
4a-(S-cysteinyl)flavin mononucleotideUnrated 4a-(S-cysteinyl)FMNUnrated MOD_RES S-4a-FMN cysteineUnrated (R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acidUnrated S4aFMNCysUnrated S-(4a-FMN)-L-cysteineUnrated S-(4alpha-FMN)-L-cysteineUnrated
N6-(morpholine-2-acetyl)-lysineUnrated N-succinimidylmorpholine-2-acetate N6-derivatized lysineUnrated
N-methylmaleimide modified L-cysteineUnrated
guanidinationkUnrated L-homoarginineUnrated
(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acidUnrated CARBOHYD O-linked (FucNAc) serineUnrated O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serineUnrated O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serineUnrated O3-(N-acetylfucosaminyl)serineUnrated OFucNAcSerUnrated O-(N-acetylamino)fucosyl-L-serineUnrated O-(N-acetylfucosaminyl)serineUnrated O-seryl-beta-N-acetylfucosaminideUnrated
2-amino-3-(aminocarbonyl)sulfanylpropanoic acidUnrated 2-amino-3-(aminocarbonyl)thiopropanoic acidUnrated alpha-amino-beta-carbamylthiopropionic acidUnrated beta-carbamylthioalanineUnrated MOD_RES S-carbamoylcysteineUnrated (R)-2-amino-3-(carbamoylsulfanyl)propanoic acidUnrated S-(aminocarbonyl)cysteineUnrated S-carbamoylcysteineUnrated S-carbamoyl-L-cysteineUnrated S-carbamylcysteineUnrated SCbmCysUnrated S-cysteinyl carbamate esterUnrated
ethanedithiol/TFA cyclic adductUnrated
fucosylated biantennary (-1 galactose) N4-glycosylated asparagineUnrated
(carbamoylmethyl)aminoUnrated iodoacetamide derivatized amino-terminal residueUnrated
tungsten containing modified residueUnrated WResUnrated
3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoylUnrated TMT6plex-127 reporter+balance reagent acylated residueUnrated
crosslinked N-formyl-L-methionine residueUnrated
dPhosOPhosThrUnrated O-phospho-L-threonine with neutral loss of phosphateUnrated
(2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acidUnrated 4-hydroxy-D-valineUnrated D-4HyValUnrated D-gamma-hydroxyvalineUnrated MOD_RES D-4-hydroxyvalineUnrated
morpholine-2-acetylated residueUnrated N-succinimidylmorpholine-2-acetate derivativeUnrated
H+NResUnrated protonated residueUnrated
N6-hexosaminylated lysineUnrated
OMeResUnrated O-methylated residueUnrated
(7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acidUnrated barley lipid transfer protein modificationUnrated cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate esterUnrated LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate esterUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ8plex-114 reporter+balance reagent O3-acylated threonineUnrated
molybdenum pterin containing modificationUnrated MoPterResUnrated
3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA)Unrated 35Hy2TyrUnrated L-3,4,5-TOPAUnrated L-3',4',5'-trihydroxyphenylalanineUnrated MOD_RES 3',4',5'-trihydroxyphenylalanineUnrated (S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acidUnrated
flavin modified residueUnrated FlavResUnrated
GPIAsnUnrated LIPID GPI-anchor amidated asparagineUnrated N-asparaginyl-glycosylphosphatidylinositolethanolamineUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ8plex-113 reporter+balance reagent acylated N-terminalUnrated
2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acidUnrated (2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acidUnrated 3-(L-cystein-S-yl)-L-tyrosineUnrated 3-(S-L-cysteinyl)-L-tyrosineUnrated CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr)Unrated S-(tyros-3'-yl)cysteineUnrated XLNKSCys3TyrUnrated
(2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acidUnrated [(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysineUnrated N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysineUnrated
(3S)-3-carboxy-1-methylisothiazolidin-1-iumUnrated dehydromethionineUnrated L-dehydromethionineUnrated
2-(L-cystein-S-yl)-L-threonineUnrated (2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acidUnrated (2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acidUnrated alpha-(L-cystein-S-yl)-L-threonineUnrated
Sulfanilic Acid (SA), heavy C13Unrated
3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoylUnrated TMT6plex-128 reporter+balance reagent N6-acylated lysineUnrated
MOD_RES O-AMP-serineUnrated O-(phospho-5'-adenosine)-L-serineUnrated
alpha-amino 3-(carboxamidomethylthio)propanoylated residueUnrated
S-hexadecanoylated residueUnrated S-palmitoylated residueUnrated SPamResUnrated
(18)O monosubstituted L-threonineUnrated
6x(13)C,2x(15)N labeled L-lysineUnrated lys-13C615N2Unrated
carbamidomethylkUnrated iodoacetamide N6-derivatized lysineUnrated N6-(2-amino-2-oxoethyl)lysineUnrated N6-(carbamoylmethyl)lysineUnrated
amidated residueUnrated
(2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acidUnrated (2S,4R)-5-hydroxyleucineUnrated (4R)-5-hydroxyleucineUnrated delta-hydroxyleucineUnrated MOD_RES (4R)-5-hydroxyleucineUnrated
2,4,5-trichlorophenyl modified residueUnrated
carboxylated residueUnrated
geranylgeranylated residueUnrated GeranylgeranylationUnrated GergerResUnrated
Hy1ResUnrated monohydroxylated residueUnrated
1-amidated L-glutamic acidUnrated (2S)-2-amino-1-pentanediamic acidUnrated 4,5-diamino-5-oxopentanoic acidUnrated GluNUnrated isoglutamineUnrated L-glutamic acid 1-amideUnrated MOD_RES Glutamic acid 1-amideUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ8plex-114 reporter+balance reagent acylated residueUnrated
5'-uridylic-O-tyrosineUnrated hydrogen 5'-uridylate tyrosine esterUnrated MOD_RES O-UMP-tyrosineUnrated O4'-L-tyrosine 5'-uridine phosphodiesterUnrated O4'-(phospho-5'-uridine)-L-tyrosineUnrated OUMPTyrUnrated O-Uridinylylation (of Tyrosine)Unrated (S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acidUnrated
[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxideUnrated cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotideUnrated L-cysteinyl copper sulfido molybdopterin cytosine dinucleotideUnrated L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotideUnrated
ModGlnUnrated modified L-glutamine residueUnrated
SOxyResUnrated sulfur oxygenated residueUnrated
methylamine Michael addition derivatized residueUnrated
O-formyl-L-threonineUnrated
(2S)-2-amino-3-(octanoyloxy)butanoic acidUnrated LIPID O-octanoyl threonineUnrated L-threonine octanoate esterUnrated O3-octanoyl-L-threonineUnrated O-octanoylated L-threonineUnrated O-octanoyl-L-threonineUnrated OOctThrUnrated
(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acidUnrated beta-(N6-lysyl)aspartyl acidUnrated CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)Unrated isoaspartyl N6-lysineUnrated N6-(L-isoaspartyl)-L-lysineUnrated N-(beta-Aspartyl)-Lysine (Crosslink)Unrated N(epsilon)-(beta-aspartyl)lysineUnrated XLNK-4Asp-N6LysUnrated
ModAlaUnrated modified L-alanine residueUnrated
carbon monoxide dehydrogenase nickel-iron cofactorUnrated hybrid nickel-triiron clusterUnrated mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron)Unrated Ni-3Fe-2S-3O clusterUnrated tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxideUnrated
brominated residueUnrated BrResUnrated
phosphorylated residueUnrated Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine)Unrated PhosResUnrated
(2S)-2-amino-3-hydroxy-3-methylbutanoic acidUnrated 3-hydroxy-L-valineUnrated 3-hydroxyvalineUnrated 3HyValUnrated MOD_RES 3-hydroxyvalineUnrated
Cl2TyrUnrated dichlorinated tyrosineUnrated
2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosineUnrated L-glutamyl 5-omega-hydroxyceramide esterUnrated LIPID Omega-hydroxyceramide glutamate esterUnrated (S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acidUnrated
Hy1ProUnrated hydroxylationpUnrated HydroxyprolineUnrated HypUnrated monohydroxylated prolineUnrated
(4-methylpiperazin-1-yl)acetylUnrated iTRAQ8plex-119 reporter+balance reagent acylated residueUnrated
hydroxylysinohydroxynorleucineUnrated syndesineUnrated

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